Utility of 2-amino-4,5,6,8-tetrahydro-7 H-chromene-3-carbonitriles in synthesis of chromeno[2,3-d]pyrimidine and chromeno[3,2-e][1,2,4]triazolo[1,5-c]pyrimidine derivatives of pharmaceutical interest

Department of Chemistry, Faculty of Education Suez canal University, Al-Arish. Egypt

Department of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt

Department of Chemistry, Faculty of Science, Al-Azhar University at Assiut, Assiut 71524, Egypt

Department of Drug Radiation Research, National Center for Radiation Research and Technology, Cairo, Egypt

Manuscript received 29 October 1997, revised 8 September 1998, accepted 9 March 1999

Chromeno[2,3-d]pyrimidines (5, 6 and 8) have been prepared by the reaction of 2-amino-7,7-dimethy1-4-substitutedphenyl­5-oxo-4,5,6,8-tetrahydro-7H-chromene-3-carbonitriles (2a,b) with formic acid, formamide and phenyl isothiocyanate respectively. The reaction of 3-amino-4-iminochromeno12,3-dlpyrimidine (11) with formic acid, acetic anhydride and p­chlorobenzaldehyde have furnished the chromeno[3,2-e1[1,2,4]triazolo[1,5-cjpyrimidines (12, 14 and 15) respectively.