Analysis of IgA Anti-S mutans Serotype c and e in ECC Patients and Its Correlation towards Saliva Viscosity and DMFT Score

Aims: To analyze Immunoglobulin A anti-S mutans serotype c and e level and the correlation towards saliva viscosity and decayed, missing, and filled teeth (DMFT) score of Early Childhood caries (ECC) patients.

Study Design: Titer of IgA was measured from saliva samples of ECC patients using ELISA methods. 

Place and Duration of Study: Laboratory of Oral Biology Faculty of Dentistry Universitas Indonesia. Jakarta 10430 Indonesia. September-December 2016.

Methodology: Titer of IgA anti-S mutans serotype c and e and the correlation between IgA titer and saliva’s viscosity as well as DMFT score were analyzed.

Results: The titer of IgA anti-S mutans serotype c and e were 6 and 15.1, the Mann-Whitney test showed P<0.05. Levels of IgA anti-S mutans serotype c and e were in line with the saliva’s viscosity in which increasing viscosity resulted in higher level of IgA titer. Further regression analysis reveals that the titer of IgA with high viscosity of saliva contain higher titer of IgA anti-S mutans compare those lower viscosity. In addition, the data shows that DMFT score have a negative correlation with IgA anti-S mutans serotype c and e levels.

Conclusion: In ECC patients, S mutans serotype e may be more immunogenic than serotype c and higher salivary viscosity may be due to its high IgA content.