Published January 8, 2022
| Version v1
Journal article
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A fibrinogen-mimicking, activated-platelet-sensitive nanocoacervate enhances thrombus targeting and penetration of tissue plasminogen activator for effective thrombolytic therapy
Creators
- 1. Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- 2. Department of Chemical Engineering Imperial College London, South Kensington Campus
Description
Inspired by fibrinogen binding to activated platelets in thrombosis, a fibrinogen- mimicking, activated-platelet-sensitive nanocoacervate (RGD-Chi@tPA) was developed by “one-pot” coacervation through a simple electrostatic interaction between positively charged arginine-glycine-aspartic acid (RGD)-grafted chitosan and negatively charged tissue plasminogen activator (tPA) to enhance thrombus targeting and penetration for effective thrombolytic therapy.
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