Synthesis and biological activity of some benzothiazolyl thiazolidinones

Department of Chemistry, Shivaji University, Kolhapur-416 004, Maharashtra, India
E-mail : m_deshmukhl@rediffmail.com
Manuscript received 1 June 2006, accepted 22 March 2007

A facile route for the synthesis of some thiazolidinone derivatives incorporating a benzothiazole moiety has been reported. S-(2-Propanoyl)-1,3-benzothiazole (2) was synthesized by reacting 2-mercapto benzothiazole with chloroacetone in dry acetone, which was subsequently reacted with substituted aryl hydrazides to give the corresponding hydrazones (3}. These on cyclocondensation with mercaptoacetic acid in presence of glacial acetic acid yielded targeted series of benzothiazolyl thiazolidin1,1nes (4).