Synthesis and antimicrobial potential of Mannich bases of 4-chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones

Department of Chemistry, Lucknow Christian Post-Graduate College, Lucknow-226 018, Uttar Pradesh, India

E-mail : nisheethrastogi2003@yahoo.co.in

Department of Chemistry, Sri Jai Narain Post-Graduate College, Lucknow-226 001, Uttar Pradesh, India

Manuscript received 3 March 2009, accepted 26 May 2009

4-Chloro-3-{ 4-(chlorobenzyloxy)-benzoylhydrazono}-indolin-2-ones (1-4) were synthesised by the condensation of 4-(chlorobenzyloxy)-benzoylhydrazines and 4-chloroisatin. On being subjected to aminomethylation in the presence of formaldehyde and heterocyclic secondary amines, indolinones 1-4, furnished aminomethylated indolinones (Mannich bases) 5-20. The structures of the compounds have been established by means of elemental analysis and spectral data (IR, PMR and Mass). The compounds have been screened for their antimicrobial potential against human pathogenic bacteria and fungi.