Determination of alkylating agents in pure form and in pharmaceutical preparations with N-bromosuccinimide reagent

Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India

E-mail : ponamjail@rediffmail.com

Manuscript received 8 October 2004, revised 7 March 2005, accepted 19 May 2005

A simple and convenient method has been developed for the determination of some alkylating agents e.g. cyclophosphamide, chlorambucil, melphalan and busulphan in pure form and in their pharmaceutical preparation with the use of N-bromosuccinimide reagent. The value of % error, SD and CV prove the method to be precise and reproducible.