Synthesis and anticonvulsant activity of halo-substituted aryl urea and thioureas

Prabhat Engineering College, Kanpur Dehat-209 304, Uuar Pradesh, India
E-mail: mksunny63@yahoo.in
Saroj Institute of Technology & Management, Lucknow-226 004, Uttar Pradesh, India
Department of Chemistry, AI-Margeb University, AI-Khums, Libya
V.S.S.D. College, Kanpur-208 002, Uttar Pradesh, India
Manuscript received 6 November 2008, revised 15 December 2009, accepted 3 June 2010

Halo-substituted arylureas have been .prepared by condensation of halo-substituted primary arylamiue with sodium cyanate and halo-substituted arylthioureu have been prepared by condensation or halo-substituted primary arylamine with ammonium thiocyanate In presence or acid, The structures or compounds synthesized have been conftrmed by elemental analysis and spectral data. Their anticonvulsant activity was evaluated, p-bromophenyl urea and p-chloropbenyl and p-bromopbenyl thiourea were found to be most active In the maximal electro shock (MES) test. p-Bromophenyl derivatives were found least neurotoxic In the rotorod test. The results were compared with standard drug phenytoin.