Inhibitory effect of plant metabolites of Nigella sativa on conditionally pathogenic microflora of productive animals

The effectiveness of a phytobiotic based on active
metabolites of Nigella sativa L. against typical microorganisms of
opportunistic microbiocenosis of the mucous membranes of highly
productive cows was studied. Initially, the inhibitory activity of the
phytobiotic was studied on cultures of wild multi-antibiotic-resistant
isolates of P. aeruginosa and S. aureus isolated on a commercial dairy
farm. It was found that the phytobiotic had the ability to inhibit the growth
of isolates on the nutrient medium, but the severity of the inhibitory effect
varied notably. At the second stage, an experiment was conducted with the
local application of phytobiotics on cows that had inflammatory
complications of the postpartum period. The results of the experiment
showed a pronounced inhibitory effect of the phytobiotic on S. aureus, Str.
uberis, P. aeruginosa, E. cloacae, C. albicans, and P. mirabilis. There was
an involution of inflammatory symptoms and normalization of the clinical
and microbiological state of the mucous membrane after the use of a
phytobiotic preparation.