Interaction of ibuprofen with β-cyclodextrins Experimental and molecular modeling studies

Department of Chemistry, Arya Vidyapeeth College, Guwahati-781 016, Assam, India

E-mail : monalisaikia@hotmail.com     Fax : 91-361-244065

Manuscript received online 28 August 2012. accepted 27 September 2012

The aim of this work was to study the interaction of β-cyclodextrin and its chemically modified varieties (hosts) with ibuprofen (guest). For this purpose the physicochemical characterization of host-guest binary systems were carried out by UV-Visible (UV-Vis), Fourier transform infrared (FTIR) spectroscopy and quantum mechanical semi empirical Pl\13 calculation. UV-Vis and FTIR studies revealed inclusion complex formation and Pl\13 calculations correlated with the experimental findings. The adsorption of ibuprofen in aqueous solutions onto β-cyclodextrin-bonded silica phase (CDS) was also investigated with the aim of an in-depth understanding of the host-guest interaction. The kinetic behaviour of ibuprofin adsorbed on CDS revealed that the rate-limiting step may be chemical adsorption, which confirmed that adsorption of ibuprofen takes place via inclusion complexation. Scanning electron micrographic (SEM) studies showed morphological differences in the unloaded adsorbent and the changes in the adsorbed CDS.