Synthesis and antimicrobial activity of azetidin-2-one containing pyrazoline derivatives

Department of Chemistry, Patel J.B.R. Arts, Patel A.M.R. Commerce & Patel J.D.K.D. Science College, Borsad-388 540, Gujarat, India

E-mail : shailchem@yahoo.com

Department of Chemistry, Sheth L.H. Science College, Mansa, Gujarat, India

Manuscript received online 25 July 2012, revised 26 July 2012, accepted 31 July 2012

Pyrazolines are well-known and important nitrogen containing 5-membered heterocyclic compounds and various methods have been worked out for their synthesis. A new series of 3-chloro-1-{ 4-[5-(substituted phenyl)-4,5-dihydropyrazol-3-yl]phenyl}-4-(4-cholorophenyl)azetidin-2.-one are synthesized by reacting 3-chloro-1-{ 4-[3-(substituted phenyl)prop2-enoyl]phenyl}-4-(4-chlorophenyl)azetidin-2-one with 99% hydrazine hydrate. All these compounds were characterized by means of their IR, ¹H NMR, spectroscopic data and microanalysis. All the synthesized products were evaluated for their antimicrobial activity. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.