National Research Data Infrastructure for Personal Health Data (NFDI4Health): Version 2.0

Germany has accumulated a wealth of health-related personal data from well-designed cohort studies and health surveillance systems (healthy individuals) as well as clinical trials (patients) that are characterised by a deep phenotyping of study subjects with questionnaires, medical examinations and molecular/genetic profiling. Their longitudinal nature and high quality make these data a valuable research resource for the development of preventive and therapeutic measures on the individual and the population level. NFDI4Health represents an interdisciplinary research community by integrating major German institutions experienced as data holders, data analysts and methodology developers. It builds on established structures, competences and know-how and expects a rapidly growing support and participation of the research community. NFDI4Health aims to create the most comprehensive inventory of German epidemiological, public health and clinical trial data to date. NFDI4Health will build a centralised data catalogue with elaborate search functionalities, sophisticated data access management, and a data analysis toolbox, while respecting stringent requirements for privacy concerning personal health data. Standardisation services will ensure a high degree of interoperability. Use cases covering prototypical study types and areas of research will show the feasibility of a harmonised implementation of all infrastructures, tools and services in accordance with our user communities.