Synthesis and antimicrobial activity of novel N-maltosylated thiocarbamides, benzothiazolyl thiocarbamides and thiocarbamates

P. G. Department of Chemistry, Shri Shivaji College, Akola-444 001, Maharashtra, India

E-mail : mamtasangole@rediffmail.com

Manuscript received 16 March 2009. revised 07 October 2010, accepted 19 September 2011

A new class of N-maltosides has been investigated in which maltosyl isothiocyanate was readily transformed into corresponding l-hepta-O-bcnzoyi-β-D-maltosyl-3-aryl thiocarbamides, 1-hepta-O-benzoyl-β-D-maltosyl-3-substituted benzothiazolyl thiocarbamides and 1-hepta-O-benzoyl-β-D-maltosyl-0-alkyl thiocarbamates on reaction with aryl amines, 2-aminobenzothiazoles/substituted benzothiazoles and alcohols. These compound were screened for their antimicrobial activity against P. vulgaris, E. coli, S. typhimurium, S. aureus, P. aeruginosa, A. niger, Mucur and Riazoctomia.