Study of electrode kinetics and thermodynamic parameters of Metronidazole polarographically

Lab. No. 303, Department of Chemistry, University of Rajasthan, Jaipur-302 055, Rajasthan, India

E-mail : ashishgarg 101 @gmail. com

Manuscript received 04 June 2010, revised 06 September 2011, accepted 19 September 2011

The electrochemical reduction of antibacterial and antiprotozoal drug "Metronidazole" has been carried out in aqueous solution of different pH by direct current (DC) polarography. It exhibits two reduction peaks in acidic medium and one in basic medium. Along with different pH, studies of drug have been carried out with different concentrations of drug and at different temperatures. The reduction of MTZ was found to be irreversible so kinetic parameters (Kº _fh, αn) are evaluated using Meites-lsrael and Gaur-Bhargava's methods. Thermodynamic parameters such as ΔHp^≠, ΔH_v^≠, ΔG^≠ and ΔS^≠ are also evaluated.