Synthesis of monoesters monochlorides and γ-ketoesters

Department of Chemistry, Gomal University, Dera Ismail Khan, KPK, Pakistan

E-mail : miqbal_44@yahoo.com Fax : 92-966-750255

Medicinal Botanic Centre, PCSIR Laboratories Complex Peshawar, KPK, Pakistan

Manuscript received online 17 January 2014, accepted 01 July 2014

In the present work previously prepared monoesters (1-20) on treatment with thionyl chloride have been converted to monoacids monochlorides (1a-20a). The monoacids monochlorides thus obtained were treated with diethyl cadmium bromide to afford corresponding γ-ketoesters (1b-20b) in yields good. The products were purified by column chromatography and characterized by spectroscopic techniques like, UV, NMR 1D and 2D (¹H and ¹³C), IR and Mass measurements.