Synthesis, docking and biological evaluation of some NSAID derivatives of amino acids

Pharmaceutical Chemistry Division, School of Advanced Sciences, VIT University, Vellore-632 014,

Tamilnadu, India

E-mail : drmhimaja@gmail.com

Non-steroidal anti-inflammatory drugs exert analgesic, antipyretic, and anti-inflammatory effects. But the use of these drugs has several side and these side effects may be reduced by coupling them with amino acids. The coupling blocks the carboxyl group and reduces acidity. A series of NSAID derivatives of amino acids were synthesized and characterized by IR, NMR and Mass spectroscopy. Docking studies of the compounds were carried out using Hex software and the receptor taken was 3LAF (colon cancer receptor). The compounds were tested for anticancer and antioxidant activities. Anticancer activity was tested on HT-29 Cells. Antioxidant activity was tested using DPPH. Ascorbic acid was taken as standard and the absorbance was measured at 517 nm. Majority of the compounds showed good antioxidant activity.