Published October 15, 2021
| Version v2.0.0
Software
Open
carmonalab/ProjecTILs: ProjecTILs-2.0
Authors/Creators
- 1. Ludwig Center for Cancer Research, University of Lausanne
Description
ProjecTILs version 2.0
New in this version:
- Allow reference atlases to be for mouse or human, and for any cell type. See for example APC reference
- Automatic pre-filtering of cell types represented in the atlas using scGate. This replaces the automatic filtering by TILPRED. Atlas objects should contain a scGate model in the slot
ref@misc$scGate, otherwise a default T cell filter is applied. - Cell cycling scores are now calculated using UCell and the signatures from Tirosh et al. (2016) for the G1/S and G2/M phases.
- Remove dependency from TILPRED
- Implement
fast.modeoption for projection, which by-passesumap::umap.predict. This is faster and allows using reference atlases built with other methods than the umap package. - Fix some issues with meta.data classes, and remove 'Q_' prefix from barcodes of projected cells, as documented in issue #17
- More flexible implementation for reading 10x files
- Update table of mouse-human orthologs to include some genes that were missing (e.g. Lamp3 = LAMP3; H2-Aa = HLA-DQA)
Files
carmonalab/ProjecTILs-v2.0.0.zip
Files
(18.3 MB)
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md5:a94fa82e24735165df2d22dd6a2ac2e3
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Additional details
Related works
- Is supplement to
- https://github.com/carmonalab/ProjecTILs/tree/v2.0.0 (URL)