Book Publisher International
Published June 5, 2021 | Version Chapter 6
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Impact of Microarray on Supernumerary Marker Chromosome and Global Developmental Delay

Creators

  • 1. Department of Obstetrics & Gynecology, Vardhman Mahavir Medical College & Safdarjung Hospital, India.
  • 2. Department of Obstetrics & Gynecology, All India Institute of Medical Sciences, New Delhi, India.

Description

Small supernumerary marker chromosomes (sSMCs) are structurally abnormal chromosomes that are equal in size or smaller than chromosome 20 and it can be recognised or characterised by conventional karyotype analysis. The molecular characterisation of sSMCs derived from chromosome 15 in prenatal diagnosis in a 38-year-old female is presented in this paper. A combination of a detailed ultrasound examination and karyotype analysis, can provide more precise and rapid prenatal diagnosis of sSMCs.

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