Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals

Chemych Mykola, Yanchuk Svitlana, Zhuk Kateryna. Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals. Journal of Education, Health and Sport. 2021;11(07): 239-249. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.07.022

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.07.022

https://zenodo.org/record/5189580

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© The Authors 2021;

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Received: 25.06.2021. Revised: 12.07.2021. Accepted: 29.07.2021.

Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals

Mykola Chemych, Svitlana Yanchuk, Kateryna Zhuk

Sumy State University

2, Rimsky-Korsakov street, Sumy 40007, Ukraine

Mykola Chemych, ORCID ID https://orcid.org/0000-0002-7085-5448 ,

n.chemych@kinf.sumdu.edu.ua ;

Svitlana Yanchuk, ORCID ID https://orcid.org/0000-0003-0130-7947, s.yanchuk@kinf.sumdu.edu.ua

Kateryna Zhuk, ORCID ID https://orcid.org/0000-0002-9130-2623 ,

katerinazhuk11@gmail.com

Abstract

An important aspect of monitoring, further timely and effective treatment of HIV-TB coinfection is timely and correct diagnosis based on comprehensive clinical, laboratory and instrumental studies. Many factors play a role in the development of tuberculosis in HIV-infected people, but the key and quite important elements are the study of genetic markers and biomarkers of inflammation. A number of studies have been carried out on inflammatory markers, but IL-6, INF-γ, MIG, CRP, IL-18 remain relevant and insufficiently studied in coinfection. A comprehensive study of them will be important in the screening of HIV-TB coinfection). Determining the presence of (SNP) rs4331426 located in chromosome 18q11.2 in HIV-infected and AIDS patients will solve the issue of predisposition to the development of tuberculosis in the early stages of HIV infection and contribute to the development of further tactics of patients treatment and management.

Keywords: HIV infection; tuberculosis; coinfection; biomarkers of inflammation; genetic markers, diagnosis.