Advantages of using graph databases to explore chromatin conformation capture experiments
- 1. Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Genoa, Italy
- 2. Computer Laboratory, University of Cambridge, Cambridge, UK
- 3. Computer Science Department, University of Turin, Turin, Italy
- 4. Institute for Biomedical Technologies, National Research Council of Italy, Segrate, MI, Italy
High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of DNA interactions and 3D chromosome folding at the genome-wide scale. Usually, these data are represented as matrices describing the binary contacts among the different chromosome regions. On the other hand, a graph-based representation can be advantageous to describe the complex topology achieved by the DNA in the nucleus of eukaryotic cells.