Published April 26, 2021 | Version v1
Journal article Open

Advantages of using graph databases to explore chromatin conformation capture experiments

  • 1. Institute of Electronics, Computer and Telecommunication Engineering, National Research Council of Italy, Genoa, Italy
  • 2. Computer Laboratory, University of Cambridge, Cambridge, UK
  • 3. Computer Science Department, University of Turin, Turin, Italy
  • 4. Institute for Biomedical Technologies, National Research Council of Italy, Segrate, MI, Italy


High-throughput sequencing Chromosome Conformation Capture (Hi-C) allows the study of DNA interactions and 3D chromosome folding at the genome-wide scale. Usually, these data are represented as matrices describing the binary contacts among the different chromosome regions. On the other hand, a graph-based representation can be advantageous to describe the complex topology achieved by the DNA in the nucleus of eukaryotic cells.



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DeepHealth – Deep-Learning and HPC to Boost Biomedical Applications for Health 825111
European Commission