Pathophysiological Implications of Urinary Peptides in Hepatocellular Carcinoma
Creators
- 1. Department of Gastroenterology and Hepatology, University Hospital Coventry, UK
- 2. Mosaiques Diagnostics GmbH, Germany
- 3. Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Germany
- 4. Arden Tissue Bank, University Hospital Coventry, UK
- 5. Department of Pathology, University Hospital Coventry, UK
Description
In this study, the application of capillary electrophoresis mass spectrometry enabled identification of 31 urinary peptides significantly associated with hepatocellular carcinoma diagnosis and prognosis. Further assessment of these peptides leads to prediction of cellular proteases involved in their development namely Meprin A subunit α and Kallikrein-6. Subsequent identification of the proteases was verified by immunohistochemistry in normal liver, cirrhosis and hepatocellular carcinoma. Histopathological assessment of the proteases revealed numerical gradient staining signifying their involvement in liver fibrosis and hepatocellular carcinoma formation. The discovered urinary peptides offer a potential noninvasive tool for diagnosis and prognosis of hepatocellular carcinoma.
Notes
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