Published June 2, 2021
| Version 1
Dataset
Open
Major facilitator superfamily domain-containing protein 10 (MFSD10) A Target Enabling Package (TEP)
Description
MFSD10 (also known as TETRAN in humans) has been proposed to function as an organic anion efflux pump and as a transporter for some NSAIDs. We have produced milligram quantities of purified recombinant protein and solved its structure in an outward-facing state at 2.6 Å resolution by X-ray crystallography. The structure - the first example for a human atypical SLC - provides the initial clues to understanding the broad specificity of its putative substrate-binding site.
Notes
This document represents version 1 of the TEP datasheet and includes all updates on the project as of June 2021. For more information about TEPs and the TEP Programme, please visit https://www.cmd.ox.ac.uk/resources/teps
Files
TETRAN TEP_v1 .pdf
Files
(1.7 MB)
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Additional details
Funding
- A UK Hub to Catalyse Open Target Discovery. 106169
- Wellcome Trust