Published July 16, 2021
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Catalyst and Additive-Free Synthesis of Fluoroalkoxyquinolines
- 1. Chemical Technology Division, CSIR-IHBT, Palampur, India
Description
A nucleophilic substitution approach is developed for the synthesis of C4 fluoroalkoxyquinolines from 4-haloquinolines. HFIP and TFE were utilized as a nucleophile. The method is also applicable for 2-chloroquinolines, 1-chloroisoquinoline and 2-chlorobenzimidazole. Control experiment revealed that substitution occurs only at C2 and C4 position of quinoline.
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- Journal article: 10.1055/a-1531-2248 (DOI)