Data from: Cortical microstructure in the amyotrophic lateral sclerosis-frontotemporal dementia continuum
Creators
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Illán-Gala, Ignacio1
- Montal, Victor2
- Pegueroles, Jordi2
- Vilaplana, Eduard2
- Alcolea, Daniel2
- Dols-Icardo, Oriol2
- Luna, Noemi de2
- Turon-Sans, Janina2
- Cortés-Vicente, Elena2
- Martinez-Roman, Luis Eduardo2
- Sánchez-Saudinós, María Belén2
- Subirana, Andrea2
- Videla, Laura2
- Sala, Isabel2
- Barroeta, Isabel2
- Valldeneu, Sílvia2
- Blesa, Rafael2
- Clarimon, Jordi2
- Lleó, Alberto2
- Fortea, Juan2
- Rojas-Garcia, Ricardo2
- 1. Hospital de la Santa Creu i Sant Pau*
- 2. .
Description
Objective: We aimed to characterize cortical macro- and micro-structure of behavioral and cognitive changes along the amyotrophic lateral sclerosis (ALS) – frontotemporal dementia (FTD) continuum.
Methods: We prospectively recruited 88 participants with a three-Tesla MRI structural and diffusion-weighted imaging sequences: 31 ALS, 20 bvFTD, and 37 cognitively normal controls. ALS participants underwent a comprehensive cognitive and behavioral assessment and were dichotomized in ALS without cognitive or behavioral impairment (ALSno-cbi, n=12) and ALS with cognitive or behavioral impairment (ALScbi, n=19). We computed cortical thickness and cortical mean diffusivity using a surface-based approach and explored the cortical correlates of cognitive impairment with the Edinburgh Cognitive and Behavioral Amyotrophic lateral sclerosis Screen (ECAS).
Results: ALSno-cbi and ALScbi groups showed different patterns of reduced cortical thickness and increased cortical mean diffusivity. In the ALSno-cbi group, cortical thinning was mainly restricted to the dorsal motor cortex. In contrast, in the ALScbi group, cortical thinning was observed primarily on fronto-insular and temporal regions bilaterally. There were progressive cortical mean diffusivity changes along the ALSno-cbi, ALScbi, and bvFTD clinical continuum. Importantly, ALS participants with either cognitive or behavioral impairment showed increased cortical mean diffusivity in the prefrontal cortex in the absence of cortical thickness.
Conclusions: Cortical mean diffusivity might be a useful biomarker for the study of extra motor cortical neurodegeneration in the ALS-FTD clinical spectrum.
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