Published January 1, 2022
| Version v1
Dataset
Open
Genome-wide association analyses identify novel Brugada syndrome risk loci and highlight a new mechanism of sodium channel regulation in disease susceptibility
Creators
- 1. Université de Nantes, CHU Nantes, CNRS, INSERM, l'institut du thorax, Nantes, F-44000, France
- 2. Amsterdam UMC, University of Amsterdam, Department of Clinical and Experimental Cardiology, Heart Centre, Amsterdam Cardiovascular Sciences, Meibergdreef 9, Amsterdam, Netherlands
Description
The Brugada syndrome GWAS summary statistics
Brugada syndrome is a cardiac arrhythmia disorder associated with sudden death in young adults. With the exception of SCN5A, encoding the cardiac sodium channel NaV1.5, susceptibility genes remain largely unknown. We performed a genome-wide association meta-analysis comprising 2,820 unrelated cases with Brugada syndrome and 10,001 controls.
Notes
README
chr: chromosome
pos: genomic position in GRCh37
rsid: dbSNP ID (if available)
effect_allele: effect allele
other_allele: other allele
beta: meta-analysis association regression coefficient
se: standard error of beta
p: P value of the association testing
n_cohorts: number of cohorts included in the meta-analysis for the specific variant
n_all: total number of samples
n_cases: total number of cases
n_controls: total number of controls
direction: direction of effect for each of the 10 cohorts
hetISq: I^2 from the meta-analysis heterogeneity test (METAL)
hetChiSq: ChiSq from the meta-analysis heterogeneity test (METAL)
hetDf: Degrees of freedom in the meta-analysis heterogeneity test (METAL)
hetPVal: P-value of the meta-analysis heterogeneity test (METAL)
eaf_all: effect allele frequency overall
eaf_cases: effect allele frequency in cases
eaf_controls: effect allele frequency in controls
Files
Barc_BrS_GWAS_sumstats.txt
Files
(866.5 MB)
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Additional details
Funding
- RISTRAD – Risk Stratification for Sudden Cardiac Death 661617
- European Commission
- EScORIAL – Emerging Simplex ORigins In ALS 772376
- European Commission
- LEARN – Molecular mechanism of a new cardiac syndrome associated with an enhancer deletion ANR-20-CE14-0026
- Agence Nationale de la Recherche
- GenSuD – A genetic survey on sudden cardiac death ANR-14-CE10-0001
- Agence Nationale de la Recherche