A cerebellar internal model calibrates a feedback controller involved in sensorimotor control

This upload contains datasets from the manuscript by Markov et al., 2021 "A cerebellar internal model calibrates a feedback controller involved in sensorimotor control" (preprint here; the code used to acquire and process these data can be found here). The datasets are organized in the following zip folders:

• behavioral_data.zip contains data from acute reaction and long-term adaptation experiments for wild-type control, treatment control, and Purkinje-cell-ablated zebrafish larvae
• feedback_control_model.zip contains parameters of the model after fitting it to the data acquired during the acute reaction experiment.
• PC_ablation_quantification.zip contains confocal images of the cerebella of zebrafish larvae before and after pharmaco-genetic ablation of Purkinje cells.
• reference_brain_stacks.zip contains z-stacks used for anatomical registration of the functional imaging data
• whole_brain_imaging_inetgrators.zip contains whole-brain light-sheet data acquired while zebrafish larvae were performing optomotor response to forward moving grating. This dataset was used to identify sensory integrators in the larval zebrafish brain
• PC_imaging_long_term_adaptation.zip contains light-sheet recordings of Purkinje cell activity acquired during long-term adaptation to lagged visual feedback. This dataset was used to identify signatures of internal models in the Purkinje cell activity.
• whole_brain_imaging_long_term_adaptation.zip contains whole-brain light-sheet recordings during long-term adaptation to lagged visual feedback. This dataset was used to study correlates of the long-term adaptation in the entire brain (such as change in sensory integration time constants).

For any question about the data, please write at ruben.portugues@tum.de or daniil.markov@charite.de.