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Published May 4, 2017 | Version v1
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Data from: The global antigenic diversity of swine influenza A viruses

Creators

  • 1. University of Cambridge
  • 2. Technical University of Denmark
  • 3. University of Edinburgh
  • 4. Wellcome Trust
  • 5. Erasmus University Medical Center
  • 6. National Institute of Animal Health
  • 7. University of Hong Kong
  • 8. Swine Virology Immunology Unit, Anses, Ploufragan-Plouzané Laboratory, Ploufragan, France*
  • 9. St. Jude Children's Research Hospital
  • 10. Ghent University
  • 11. Animal and Plant Health Agency
  • 12. United States Department of Agriculture
  • 13. Rega Institute for Medical Research

Description

Swine influenza presents a substantial disease burden for pig populations worldwide and poses a potential pandemic threat to humans. There is considerable diversity in both H1 and H3 influenza viruses circulating in swine due to the frequent introductions of viruses from humans and birds coupled with geographic segregation of global swine populations. Much of this diversity is characterized genetically but the antigenic diversity of these viruses is poorly understood. Critically, the antigenic diversity shapes the risk profile of swine influenza viruses in terms of their epizootic and pandemic potential. Here, using the most comprehensive set of swine influenza virus antigenic data compiled to date, we quantify the antigenic diversity of swine influenza viruses on a multi-continental scale. The substantial antigenic diversity of recently circulating viruses in different parts of the world adds complexity to the risk profiles for the movement of swine and the potential for swine-derived infections in humans.

Notes

Figure 1. Source data 1
Figure 1. Source data 1 - Input and output text files containing all H1 and H3 virus data used in Figure 1, Figure1 Supplemental 1,2,3, files
Figure1.Source data 1.zip
Figure 2. Source data 2
Figure 2. Source data 2 - Input and output text files used to calculate H1 and H3 comparative rates of antigenic evolution and diversity shown in Figure 2 and Supplementary File 3_ Table 3
Figure2.Source data 2.zip
Supplemental Table 1. Source Data
Supplemental Table 1. Source Data - Text files and plots of summary statistics of testing in 1, 2, 3, 4 and 5 dimensions
Supplemental Table1.Source Data.zip
Supplemental Table 2. Source data
Supplemental Table 2.Source data Text infiles, phylogenetic trees and source script for antigenic distance analyses
Supplemental Table 2.Source data.zip
Figure 1A
gif files for rotational views of 3D antigenic maps in Figure 1
Figure1A.H1_lineages.gif
Figure 1B
gif files for rotational views of 3D antigenic maps in Figure 1
Figure1B.H1_regions.gif
Figure 1C
gif files for rotational views of 3D antigenic maps in Figure 1
Figure1C.H3_lineages.gif
Figure 1D
gif files for rotational views of 3D antigenic maps in Figure 1
Figure1D.H3_regions.gif

Files

Figure1.Source data 1.zip

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Additional details

Related works

Is cited by
10.7554/eLife.12217 (DOI)