CATH Functional Families assignments for SARS-CoV-2, SARS-CoV and MERS proteins

CATH Functional Families (FunFams) are coherent subsets of protein domain sequences that share the same function within the same CATH SuperFamily.

The latest release of CATH, v4.3, was frozen before the COVID-19 pandemic, therefore structural domains from SARS-CoV-2 and the FunFams assignments are not part of the CATH website.

The assignments in these files file were obtained by scanning the UniProt entries of SARS-CoV-2, SARS and MERS against the FunFams v4.3 Hidden Markov Models library using HMMER3 and resolved using cath-resolve-hits.