Published March 10, 2020 | Version v1
Dataset Open

Increasing the sensitivity of hyperpolarized [15N2]urea detection by serial transfer of polarization to spin-coupled protons

  • 1. Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK
  • 2. Department of Radiology, Faculty of Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel
  • 3. Cancer Research UK Cambridge Institute and Department of Biochemistry, University of Cambridge, Cambridge, UK


This upload contains the raw data, MATLAB scripts and Mathematica notebooks used for the publication.

Figure 2, 3, 7 and 8 where generated with the Mathematica notebooks in the folder Mathematica_Notebooks.

Figure 4 was generated with the raw data in NOE_data/20190821 and processed with the script NOE_data/20190821/H1to15NNOEin15N2urea.m

Figure 5a is based on data in Polarization_Transfer_Data/spectral/timecourse/_fk_BHINDER_flipback_15Nto1H_hyp_20180609_01.fid processed with Polarization_Transfer_Data/spectral/timecourse/_fk_BHINDER_flipback_15Nto1H_hyp_20180609_01.fid/timecourse.m

Figure 5b is based on Polarization_Transfer_Data/imaging/_fk_BHINDER_flipback_EPIP_hyp_10perc_20180531_01.img . From this raw data image2 - image60 are acquired after polarisation transfer. Image1 is a direct acquisition of the water resonance .

The brightness and contrast of the images was adjusted and a montage of images 2 to 9  was created with (Fiji .

Figure 6 is based on data in Polarization_Transfer_Data/spectral/interleaved processed with Polarization_Transfer_Data/spectral/interleaved/comparision.m

The script Pulse_Generation/createIRRUPT.m was used to generate the adiabatic pulses.


Files (28.4 MB)

Name Size Download all
28.4 MB Preview Download

Additional details


AlternativesToGd – Hyperpolarised MR technologies and molecular probes as alternatives for conventional metal-containing contrast agents for MRI examinations 858149
European Commission
European Commission