Published August 26, 2015 | Version v1
Journal article Open

Physical and Structural Characterization of Biofield Treated Imidazole Derivatives

Creators

  • 1. Trivedi Global Inc.
  • 2. Trivedi Science Research Laboratory Pvt. Ltd.

Description

Imidazole derivatives have attracted significant interests in recent time for their usefulness in synthetic heterocyclic chemistry, analytical chemistry and pharmacology. Aim of present study was to evaluate the impact of biofield treatment on two imidazole derivatives (i.e., imidazole and 2-methylimidazole) by various analytical methods. The biofield treatment was done by Mr. Trivedi on both the compounds and both control and treated samples of imidazole and 2-methylimidazole were characterized with respect to physical, and structural properties using X-ray diffraction (XRD), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), Fourier transform infrared (FT-IR), ultraviolet-visible (UV-Vis) spectroscopy, and Gas chromatography-Mass spectrometry (GC-MS). X-ray diffraction study revealed that crystallite size varied in a different way for imidazole and 2-methylimidazole due to the presence of methyl group in 2-c position although their core was same. Treated sample of imidazole showed a slight increase in crystallite size (6.5%); however, treated 2-methylimidazole showed a significant increase (166.68%) in crystallite size along with decrease in peak intensity as compared to control. The latent heat of fusion (ΔH) of imidazole was increased up to 0.62% in treated sample as compared to control; whereas in treated 2-methylimidazole, the ΔH was decreased by 22% as compared to control. Maximum degradation temperature (Tmax) from TGA of imidazole was remained same but 2-methylimidazole was increased by 1.5% as compared to control. FT-IR spectra showed slight change in stretching frequencies of treated imidazole and 2-methylimidazole as compared to control. Both the imidazole and 2-methylimidazole showed similar UV absorbance maxima as compared to respective control sample. GC-MS data revealed that isotopic abundance ratio of either 13C/12C or 15N/14N or 2H/1H (PM+1/PM) of treated imidazole was significantly increased up to 232.51% as compared to control, however, isotopic abundance ratio of 13C/12C or 15N/14N or 2H/1H (PM+1/PM) of treated 2-methylimidazole showed a minor change from -1.68 upto 1.68% as compared to control. Overall, the experimental results suggest that biofield treatment has significant effect on structural and thermal properties of imidazole and 2-methylimidazole.

Source:

Notes

Trivedi MK, Branton A, Trivedi D, Nayak G, Saikia G, et al. (2015) Physical and Structural Characterization of Biofield Treated Imidazole Derivatives. Nat Prod Chem Res 3: 187. doi:10.4172/2329-6836.1000187

Files

physical-and-structural-characterization-of-biofield-treated-imidazolederivatives-2329-6836-1000187.pdf

Files (2.2 MB)

Additional details

Related works

Is cited by
http://library.harvard.edu/ (URL)

References

  • Verma A, Joshi S, Singh D (2013) Imidazole: Having versatile biological activities. J Chem 2013: 1-12.
  • Singhand H, Kapoor VK (2008) Medicinal and pharmaceutical chemistry (2ndedn). Vallabh Prakashan, New Delhi.
  • Starcevic K, Kralj M, Ester K, Sabol I, Grce M, et al. (2007) Synthesis, antiviral and antitumor activity of 2-substituted-5-amidino-benzimidazoles. Bioorg Med Chem 15: 4419-4426.
  • Vijesh AM, Isloor AM, Telkar S, Peethambar SK, Rai S, et al. (2011) Synthesis, characterization and antimicrobial studies of some new pyrazole incorporated imidazole derivatives. Eur J Med Chem 46: 3531-3536.
  • Ucucu U, Karaburun NG, Isikdag I (2001) Synthesis and analgesic activity of some 1-benzyl-2-substituted-4,5-diphenyl-1H-imidazole derivatives. Farmaco 56: 285-290.
  • Yang WC, Li J, Chen Q, Yang GF (2012) Novel synthetic methods for N-cyano-1H-imidazole-4-carboxamides and their fungicidal activity.Bioorg Med Chem Lett 22: 1455-1458.
  • Yang W, Wan X, Deng (2012) Design, synthesis and cytotoxic activities of novel hybrid compounds between 2-phenylbenzofuran and imidazole. Bioorg Med Chem Lett 22: 2726-2729.
  • Trivedi MK, Patil S, Shettigar H, Bairwa K, Jana S (2015) Phenotypic and biotypic characterization of Klebsiella oxytoca: An impact of biofield treatment. J Microb Biochem Technol 7: 203-206.
  • Rivera-Ruiz M, Cajavilca C, Varon J (2008) Einthoven's string galvanometer: The first electrocardiograph. Tex Heart Inst J 35: 174-178.
  • Rubik B (2002) The biofield hypothesis: Its biophysical basis and role in medicine. J Altern Complement Med 8: 703-717.
  • Trivedi MK, Patil S, Tallapragada RMR (2015) Effect of biofield treatment on the physical and thermal characteristics of aluminium powders. Ind Eng Manage 4: 151.
  • Trivedi MK, Patil S, Shettigar H, Gangwar M, Jana S (2015) Antimicrobial sensitivity pattern of Pseudomonas fluorescens after biofield treatment. J Infect Dis Ther 3: 222.
  • Sances F, Flora E, Patil S, Spence A, Shinde V (2013) Impact of biofield treatment on ginseng and organic blueberry yield. Agrivita J Agric Sci 35.
  • Lenssen AW (2013) Biofield and fungicide seed treatment influences on soybean productivity, seed quality and weed community. Agricultural Journal 8: 138-143.
  • Patil SA, Nayak GB, Barve SS, Tembe RP, Khan RR (2012) Impact of biofield treatment on growth and anatomical characteristics of Pogostemon cablin (Benth.). Biotechnology 11: 154-162.
  • Barszcz B, Kulig J, Jezierska J, Lisowski J (1999) The role of the side group in reactions involving 1-propyl-2-methylimidazole and 1-propyl-2-imidazole-carboxaldehyde and Co(II), Ni(II), Cu(II) and Zn(II) ions. Pol J Chem 73: 447-456.
  • Zhao L, Sheng BL, Gui AW, Peng B, Wei H (2006) Imidazole derivatives: Thermally stable organic luminescence materials. Mater Chem Phys 100: 460-463.
  • Martinez-Carrera S (1966) The crystal structure of imidazole at -150°C. Acta Cryst 35: 783-789.
  • Rashidi AM, Amadeh A (2009) The effect of saccharin addition and bath temperature on the grain size of nanocrystalline nickel coatings. Surf Coat Technol 204: 353-358.
  • Gusain D, Srivastava V, Singh VK, Sharma YC (2014) Crystallite size and phase transition demeanor of ceramic steel. Mater Chem Phys 145: 320-326.
  • Waser M (2012) Asymmetric Organocatalysis in Natural Product Syntheses (Progress in the Chemistry of Organic Natural Products). Springer Science & Business Media, New York, US.
  • Trivedi MK, Patil S, Tallapragada RM (2013) Effect of biofield treatment on the physical and thermal characteristics of silicon, tin and lead powders. J Material Sci Eng S 111-136.
  • Trivedi MK, Nayak G, Patil S, Tallapragada RM, Latiyal O, et al. (2015) The potential impact of biofield treatment on physical, structural and mechanical properties of stainless steel powder. J Appl Mech Eng 4: 1-5.
  • Califano S (1976). Vibrational States. New York: Wiley.