VariantEffect/mavedb: 2.0.0

This is a major update that includes numerous improvements, particularly in dataset validation.

• Saturation genome editing data is now supported, with a new hgvs_tx column that can describe splice variants.
• The dataset search page has been rewritten to be more usable and more performant.
• Variants are now represented using the format defined by MAVE-HGVS. This is very similar to the previous Enrich2-like format, but please consult the documentation for key differences.
• Variants are now validated against the target sequence on upload.

• Additional raw data accessions (GEO, ArrayExpress) are now supported.
• A new admin page has been added to simplify database administration for staff.
• MaveDB can now be deployed using Docker Compose. Developers should consult the new developer documentation for instructions on how to get a local instance up and running.