Published September 22, 2020 | Version v1
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Lewis Acid Promoted Dearomatization of Naphthols

Creators

  • 1. University of Groningen

Description

Two‐step dearomative functionalization of naphthols promoted by Lewis acids and copper(I) catalysis was developed. Initially, Lewis acid complexation inverted the electronic properties of the ring and established an equilibrium with the dearomatized counterpart. Subsequent trapping of the dearomatized intermediate with organometallics as well as organophosphines was demonstrated and provided the corresponding dearomatized products.

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Funding

European Commission
LACOPAROM – Lewis acid promoted copper catalysis to functionalise and dearomatise arenes 773264