Immunopathology of Multiple Sclerosis

After decades of experimental and clinical investigations regarding to immunomodulatory therapies for
multiple sclerosis (MS) point to exact immunological pathogenesis that drive disease relapses, progression,
and remission. In this regard, we shed a light on our current information on multiple sclerosis
immunopathogenesis, assess strong hypotheses about the role of the immune system in the disease and clarify
key controversies that are still unresolved. Recent clinical recognitions in the field of immunology, and the
increasing advances with respect to the role of inflammation as a pivotal component of demyelination, are
shaping our findings of disease immunopathogenesis, and we evaluate the concepts for improved efficacy of
current treatments of MS in the future.