The alleles C677T - A1298C methylenetetrahydrofolate reductase

^{The alleles C677T - A1298C methylenetetrahydrofolate reductase}

M T H F R: Homocysteine metabolism is linked to DNA methylation, but also to the decoding of antibodies for the immune system, through histone methylation, a mechanism potentially involved in the course of virus infection.

In a study published in the journal "NCBI National Center for Biotechnology Information (Pubmed.gov)" "the hepatitis B virus (HBV) was studied by evaluating the association of the determinants of homocysteine metabolism with the outcome of HBV infection. The research was carried out on a sample of four hundred and fifty-five healthy adults from West Africa, testing serological markers HBV, HLA DR alleles, folate, vitamin B12, methylenetetrahydrofolate reductase (MTHFR) 677 C -> T, 1298 A -> C and methionine synthase. 2756 A -> G polymorphisms. The attenuated results are: 68% of the population were positive for anti-HBc. Among them, 202 (56.9%) were anti-HBs positive and 58 (16.3%) were HBsAg positive. After gradual logistic regression, the MTHFR 677 T allele was independently associated with the persistence of detectable anti-HBs antibodies. The mean HBV DNA level was significantly lower in HBsAg positive subjects carrying the 677T allele than in those with the 677CC genotype. In conclusion, it was found that the methylenetetrahydrofolate reductase 677T allele appears to protect against chronic HBV infection in young African adults. "* J Hepatol. 2008 Apr; 48 (4): 532-9. doi: 10.1016 / j.jhep.2007.11.017. Epub 2008 Jan 2.

HYPOTHESIS: Following the scientific research, cited, being a Virus, using the mathematical expression "self-similarity, (1975 B. Mondelbront French mathematician) it follows that subjects with mutated genetic expression of the MTHFR alleles, against the Sars-Cov2 virus , having been discovered the link with the MTHFR C677T and A1298C alleles, the same behavior emerges, therefore in these subjects, who have inherited the defect of these genes, they are unable to receive stimulation of antibodies, nor to produce adequate defenses for lack of the same methyltetrahydrofolate allele, for inherited constitutional relationships of the parents, transmitted by autosomal recessive. From the studies found in Europe, Italy is the first in the ranking with a percentage of 62% of the population for this mutation. In order to protect the health of all citizens, it emerges recently that the alleles in question MTHFR C677T and A1298C, were requested by the Italian prosecutors, to clarify the deaths that occurred after the administration of vaccines, therefore it results that people carrying this mutation does not seem suitable for vaccinations, given the investigations in progress, since this study already shows the constitutional impossibility of receiving stimulations or producing adequate quantities, invalidating the vaccination itself, created for the purpose of producing antibodies, and that in these subjects , it is not possible, by natural genetic means, to build antibodies, endangering the life of the same, which fall into the list of Rare diseases, under the code RGD020. Given the high percentage of this mutation in the world, which is between 40% and 60% of the population, without distinction of race, with varying percentages, the self-similarity emerges, which photographs current events. In fact, the first in the world to have been affected by Covidi-19 and to have the highest percentage of the MTHFR genetic mutation, are: Italians, Americans, Hispanics, to climb other nationalities, the same ones most affected by Sars-Vov2 . It must also be said that this mutation was already known in 1995 during the study of the human genome, which ended in 2003. The research can be viewed in the AJE American Journal of Epidemiology Vol. 151, No.9 - year 2000.

Luigi Barone