Published April 14, 2021 | Version v1
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Isothermal Titration Calorimetry of fragments and Nsp3 macrodomain of SARS-CoV-2

  • 1. University of California, San Francisco


This directory contains all files required to analyze the Isothermal Titration Calorimetry (ITC) data presented in the manuscript.

ITC was performed using a MicroCal iTC200 and data was previewed using Origin ( Analysis was performed using RITC (

Files included in this directory:
- tracking sheet of all ITC experiments performed for manuscript.
- includes information on experimental conditions for individual experiments.

Docking Fragments 
- contains sub-directories for each compound tested by ITC. Each sub-directory contains raw ITC files (.itc), Origin Project files (.OPJ), images of isotherm (.png), and experimental values for analysis (.csv).

- contains images of isotherm (.png) and experimental values for analysis (.csv) for all compounds reported. Figures (.png) as shown in manuscript appear in sub-directory "
- reports R^2, Ka, ∆H, and Heat of Dilution for each compound analyzed using RITC.



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Additional details

Related works

Is supplement to
Preprint: 10.1101/2020.11.24.393405v1 (DOI)
Journal article: 10.1126/sciadv.abf8711 (DOI)