Intracardiac hemodynemics, fibroblast growth factor-2 and oxyproline levels with mitral valve prolapse in combination with type 1 diabetes mellitus

Nikolenko  O., Korzh O. Intracardiac hemodynemics, fibroblast growth factor-2 and oxyproline levels with mitral valve prolapse in combination with type 1 diabetes mellitus. Journal of Education, Health and Sport. 2020;10(12):304-313. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.12.030

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.12.030

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Received: 09.11.2020. Revised: 25.11.2020. Accepted: 17.12.2020.

INTRACARDIAC HEMODYNEMICS, FIBROBLAST GROWTH FACTOR-2 AND OXYPROLINE LEVELS WITH MITRAL VALVE PROLAPSE IN COMBINATION WITH TYPE 1 DIABETES MELLITUS

O. Nikolenko1  O. Korzh2

1V. N. Karazin Kharkiv National University

Department of General Practice - family medicine

2Kharkiv Medical Academy of Postgraduate Education

Department of General Practice - family medicine

olena.nikolenko.kh@gmail.com

Nikolenko O. https://orcid.org/0000-0003-1001-5356

Korzh O. https://orcid.org/0000-0001-6838-4360

Abstract

The purpose. The aim of the study was a comparative analysis of basic echocardiographic parameters, fibroblast growth factor-2 and free and peptide-bounding oxyproline indicators in young patients with mitral valve prolapse, type 1 diabetes mellitus and the combination of both indications.

Materials and methods. 93 patients between 19 and 33 years old with either mitral valve prolapse, type 1 diabetes and the combination of both indications were examined.  There are 24 people with diagnosed mitral valve prolapse, 33 patients with type 1 diabetes mellitus and mitral valve prolapse and 36 patients with the monomorbid type 1 diabetes mellitus. The establishment of the diagnosis of mitral valve prolapse implemented by echocardiographic criteria L. Freed et al. (2002). The concentration of fibroblast growth factor-2 in blood plasma was determined by the enzyme immunoassay using a Quantikine reagent kit (Human FGF basic Immunoassay), manufactured by R&D Systems, Inc. (USA) and expressed in pg/ml. Free and peptide-bounding oxyproline as the markers of connective tissue metabolism were determined by the method of P. N. Sharaev and expressed in µmol/L.

Results. In patients with mitral valve prolapse and ype 1 diabetes mellitus, the higher values of l left ventricular posterior wall thickness and intraventricular septum have been revealed in comparison with the groups of patients with monomorbid mitral valve prolapse and ype 1 diabetes mellitus. Fibroblast growth factor-2 was higher in group with combination of both indications, where it was [23.7 ± 0.25] pg/ml compared to the control group [14.20 ± 0.22] pg/ml (p <0.01). There was also a significant difference in the levels of fibroblast growth factor-2 between group with either mitral valve prolapse [15.33 ± 0.24] pg/ml and combination of mitral valve prolapse and type 1 diabetes [23.71 ± 0.25] pg/ml (p<0.01). The level of peptide-bound oxyproline, just as the level of free oxyproline, significantly increased in patients with comorbid pathology, compared to the control group: [16.06 ± 1.54] µmol/l versus [8.7 ± 0.81] µmol/l (p<0.01) respectively.

Conclusions. The most significant differences in the indices of intracardiac hemodynamics, fibroblast growth factor-2 and free and peptide-bounding oxyproline compared with control were observed in patients with combination of mitral valve prolapse and type 1 diabetes, which may indicate the influence of diabetic metabolic processes on further structural changes in the mitral valve.

Keywords: mitral valve prolapse; diabetes mellitus; fibroblast growth factor-2; free and peptide-bound oxyproline; cardiac valve degeneration; echocardiographic parameters of left ventricular hemodynemic.