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Published January 28, 2021 | Version v1
Journal article Open

Natural products in drug discovery: advances and opportunities

Creators

  • 1. Institute of Genetics and Animal Biotechnology of the Polish Academy of Sciences, Jastrzebiec, Poland; Department of Pharmacognosy, University of Vienna, Vienna, Austria.; Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.; Ludwig Boltzmann Institute for Digital Health and Patient Safety, Medical University of Vienna, Vienna, Austria.
  • 2. Department of Pharmacognosy, University of Vienna, Vienna, Austria.
  • 3. Università degli Studi di Firenze, NEUROFARBA Dept, Sezione di Scienze Farmaceutiche, Florence, Italy
  • 4. Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey
  • 5. Polish Mother's Memorial Hospital Research Institute (PMMHRI), Łodz, Poland
  • 6. Department of Pharmacognosy, University of Vienna, Vienna, Austria
  • 7. 8Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Università degli Studi di Messina, Messina, Italy
  • 8. Molecular Systems Biology (MOSYS), Department of Evolutionary and Functional Ecology, University of Vienna, Vienna, Austria; Vienna Metabolomics Center (VIME), University of Vienna, Vienna, Austria
  • 9. Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria; BioTechMed- Graz, Graz, Austria
  • 10. Department of Biomolecular Sciences, The Weizmann Institute of Science, Rehovot, Israel
  • 11. Sami Labs Limited, 19/1, 19/2, First Main, Second Phase, Peenya Industrial Area, Bangalore, Karnataka, India; Sabinsa Corporation, East Windsor, NJ, USA.; Sabinsa Corporation, Payson, UT, USA
  • 12. Lake Erie College of Osteopathic Medicine, Bradenton, FL, USA
  • 13. Institute of Analytical Chemistry and Radiochemistry, Leopold- Franzens University of Innsbruck and Austrian Drug Screening Institute — ADSI, CCB — Center of Chemistry and Biomedicine, Innsbruck, Austria
  • 14. Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, New South Wales, Australia
  • 15. Institute of Pharmaceutical Sciences, Department of Pharmacognosy, University of Graz, Graz, Austria
  • 16. Laboratory of Foodomics, Bioactivity and Food Analysis Department, Institute of Food Science Research CIAL (UAM- CSIC), Madrid, Spain
  • 17. Clinical Psychology Service, Health Department, Fondazione IRCCS 'Casa Sollievo della Sofferenza', San Giovanni Rotondo, Italy
  • 18. Evotec (UK) Ltd, Oxford, UK
  • 19. Department of Pharmacy, College of Pharmacy, Seoul National University, Seoul, South Korea
  • 20. 25Jacqui Wood Cancer Centre, Division of Cellular Medicine, School of Medicine, University of Dundee, Dundee, UK; Department of Pharmacology and Molecular Sciences and Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • 21. Department of Pharmaceutical Biology, Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg University, Mainz, Germany
  • 22. Cancer Biomarkers Working Group, Oujda, Morocco
  • 23. International Natural Product Sciences Taskforce (INPST), Jastrzebiec, Poland
  • 24. Department of Pharmacology, University of Cambridge, Cambridge, UK; College of Life Sciences, Northwest University, Xi'an, China
  • 25. Neuroimmunology and Neurochemistry Research Group, Department of Psychiatry and Psychotherapy, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • 26. Institute of Pharmacology and the Gaston H. Glock Research Laboratories for Exploratory Drug Development, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria
  • 27. Laboratory of Metabolomics, The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Plovdiv, Bulgaria; Center of Plant Systems Biology and Biotechnology, Plovdiv, Bulgaria
  • 28. Natural Products Laboratory, Institute of Biology, Leiden University, Leiden, Netherlands

Description

Abstract | Natural products and their structural analogues have historically made a major
contribution to pharmacotherapy, especially for cancer and infectious diseases. Nevertheless,
natural products also present challenges for drug discovery, such as technical barriers to screening,
isolation, characterization and optimization, which contributed to a decline in their pursuit by
the pharmaceutical industry from the 1990s onwards. In recent years, several technological and
scientific developments — including improved analytical tools, genome mining and engineering
strategies, and microbial culturing advances — are addressing such challenges and opening up
new opportunities. Consequently, interest in natural products as drug leads is being revitalized,
particularly for tackling antimicrobial resistance. Here, we summarize recent technological
developments that are enabling natural product- based drug discovery, highlight selected
applications and discuss key opportunities

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Atanasov et al. 2021.pdf

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Additional details

Funding

PlantaSYST – Establishment of a Center of Plant Systems Biology and Biotechnology for the translation of fundamental research into sustainable bio-based technologies in Bulgaria 739582
European Commission