Prevention and treatment of autoimmune diseases with plant virus nanoparticles
Creators
- Roberta Zampieri1
- Annalisa Brozzetti2
- Eva Pericolini3
- Elena Bartolini2
- Elena Gabrielli2
- Elena Rosselletti2
- George Lomonosoff4
- Yulia Meshcheriakova4
- Luca Santi5
- Francesca Imperatori5
- Matilde Merlin1
- Elisa Tinazzi1
- Francesco Dotta6
- Laura Nigi1
- Guido Sebastiani6
- Mario Pezzotti1
- Alberto Falorni2
- Linda Avesani1
- 1. Università degli studi di Verona
- 2. Università degli studi di Perugia
- 3. Università degli studi di Modena e Reggio Emilia
- 4. John Innes Centre, Norwich
- 5. Università degli studi della Tuscia
- 6. Università degli studi di Siena
Description
Plant viruses are natural, self-assembling nanostructures with versatile and genetically programmable shells, making them useful in diverse applications ranging from the development of new materials to diagnostics and therapeutics. Here, we describe the design and synthesis of plant virus nanoparticles displaying peptides associated with two different autoimmune diseases. Using animal models, we show that the recombinant nanoparticles can prevent autoimmune diabetes and ameliorate rheumatoid arthritis. In both cases, this effect is based on a strictly peptide-related mechanism in which the virus nanoparticle acts both as a peptide scaffold and as an adjuvant, showing an overlapping mechanism of action. This successful preclinical testing could pave the way for the development of plant viruses for the clinical treatment of human autoimmune diseases.
Accepted manuscript: https://advances.sciencemag.org/content/6/19/eaaz0295
Files
Zampieri_2020_Prevention and treatment autoimmune disease_plant virus.pdf
Files
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