RENAL MECHANISMS OF REGULATION OF CARBOHYDRATE STATUS IN THE DYNAMICS OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT = РЕНАЛЬНІ МЕХАНІЗМИ РЕГУЛЯЦІЇ ВУГЛЕВОДНОГО СТАТУСУ В ДИНАМІЦІ РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНОГО ЦУКРОВОГО ДІАБЕТУ.

Olenovych O. A., Boychuk T. M., Gozhenko A. I. RENAL MECHANISMS OF REGULATION OF CARBOHYDRATE STATUS IN THE DYNAMICS OF ALLOXAN-INDUCED EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT = РЕНАЛЬНІ МЕХАНІЗМИ РЕГУЛЯЦІЇ ВУГЛЕВОДНОГО СТАТУСУ В ДИНАМІЦІ РОЗВИТКУ ЕКСПЕРИМЕНТАЛЬНОГО ЦУКРОВОГО ДІАБЕТУ. Актуальні проблеми транспортної медицини / Actual problems of transport medicine / 2020;4(62):144-151. ISSN 1818-9385

DOI http://dx.doi.org/10.5281/zenodo.4396183

http://aptm.org.ua

УДК 616-008.9(075.8).

DOI: http://dx.doi.org/10.5281/zenodo.4396183

RENAL MECHANISMS OF REGULATION OF CARBOHYDRATE

STATUS IN THE DYNAMICS OF ALLOXAN-INDUCED

EXPERIMENTAL DIABETES MELLITUS DEVELOPMENT

Olenovych O. A.1, Boychuk T. M.1, Gozhenko A. I.2

1Bukovynian State Medical University, Chernivtsi, Ukraine

2SE “Ukrainian Research Institute of Transport Medicine of the Ministry of Health of

Ukraine”, Odessa, Ukraine

olenovych.olga@bsmu.edu.ua

Summary

The article presents the data concerning renal processes of regulation of carbohydrate status 11th, 26th and 46th day after the administration of diabetogenic dose of alloxan (160 mg/kg) to white non-linear matured male rats. It is established, that from the 11th to the 46th day of alloxan-induced experimental diabetes mellitus, the concentration of glucose in blood plasma remains consistently high with a simultaneous increase in its excretion. The elevation of the latter occurs against the background of an increase in the filtration load, which exceeds the ability of glucose transport in the proximal nephron, especially on the 26th and 46th day of the experiment. Therefore, the increase in glucose excretion should be considered as a consequence of the relative functional insufficiency of its reabsorption, the fluctuations of which at different stages of diabetes require further analysis.

Key words: experimental diabetes mellitus, alloxan, carbohydrate status, hyperglycemia, glucosuria, hyperfiltration.