In-silico Identification of lncRNA Functionality in Cancers Related to Obesity

In-silico Identification of lncRNA Functionality in Cancers Related to Obesity

Shalini Das, Nushrat Jahan and Chittabrata Mal

Amity Institute of Biotechnology, Amity University Kolkata, Rajarhat, Newtown, Action Area III, North 24 PGS, 700135, INDIA

shweata7@gmail.com, nushratjahan8456@gmail.com, cmal@kol.amity.edu

ABSTRACT:

Investigating the gene expression networks that regulate cancer initiation and development is crucial but remains mostly incomplete. With the innovations in RNA-sequencing technologies and computational biology, long noncoding RNAs (lncRNAs) are being known and characterized at a speedy pace. Recent findings reveal that lncRNAs are involved in serial steps of cancer development. These lncRNAs act with DNA, RNA, protein molecules and/or their combos, acting as a vital regulator in chromatin organization, as well as transcriptional and post-transcriptional regulation. Their aberrant expression confers the neoplastic cell capacities for neoplasm initiation, growth, and metastasis. Here we emphasize their aberrant expression and performance in cancers. We found that Chromosome 11 consists of the highest number of lncRNA specific to different 14 cancers related to obesity. Among these cancers, breast cancer has the highest number of lncRNA associated with it. The interacting partners of the lncRNAs were analysed and domain specific interactions were studied. The results showed that the lncRNAs H19 and MALAT1 can act as potential biomarkers for different cancers.

Keywords: lncRNA, gene expression, cancer, obesity, tumor suppression

URL: https://www.ijbst.org/papers-published/ijbst-2020-volume-13-issue-3