Published September 4, 2020 | Version v2
Dataset Open

Cayla et al., 2020, Wellcome Open Research - Underlying data

  • 1. University of Edinburgh

Description

Underlying dataset for the identifications of low-complexity regions (LCRs) in the proteome of Trypanosoma brucei.

- Supplement File 2.xlsx (Position of every InterPro domain and LCR identified. All genes are provided with indication on chromosome localisation, presence of transmembrane domains, signal peptides and the localisation of the encoded proteins, either predicted using DeepLoc37 or observed (Tryptag38)).

- Supplement File 3.xlsx (List of genes and Molecular Function gene ontology (GO) enrichment analysis of proteins with predicted LCRs in the N-terminal, central part or C-terminal or the different possible combinations.)

- Supplement File 4.xlsx (Property analysis of sequences of every InterPro and LCRs identified.)

- Supplement File 5.xlsx (List of genes and Molecular GO enrichment analysis of proteins presenting a Low (<8) or High (>9) polarity index level.)

- Supplement File 6.xlsx (List and position of PTMs present on InterPro domains and LCRs. The different datasets from which the PTMs have been extracted can be found in the Zhang2020, Benz2019, Cayla2019, Urbaniak2013, Ooi2020, Fisk2012, Lott2012 and Moretti201712,13,15,17–19,27,28 columns. The sequence properties of the domains/LCRs on which these PTMs are located are also indicated. The list of modifications identified in Ooi et al. 202028 present on LCRs are indicated in the second sheet.)

- Supplement File 7.xlsx (List and position of LCRs, signal peptides and their overlap.)

Notes

This work was also supported by the Marie Sklodowska Curie postdoctoral fellowship (proposal number 65470) and a Royal Society Research merit award [WM140045]

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Additional details

Related works

Is supplement to
Journal article: 10.12688/wellcomeopenres.16286.1 (DOI)

Funding

Wellcome Trust
Environmental sensing and cell-cell communication in African trypanosomes. 103740

References

  • Cayla et al (2020). A global analysis of low-complexity regions in the Trypanosoma brucei proteome reveals enrichment in the C-terminus of nucleic acid binding proteins providing potential targets of phosphorylation. Wellcome Open Res, 5:219 (https://doi.org/10.12688/wellcomeopenres.16286.1)