Published October 3, 2020
| Version v0
Journal article
Open
Structure-Activity Relationship and Mechanistic Studies for a Series of Cinnamylhydroxamate Derived Histone Deacetylase (HDAC) Inhibitors
Creators
- 1. Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
- 2. Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
- 3. Department of Oncology and Pneumonology, Internal Medicine VIII, University Hospital Tübingen, Otfried-Müller-Straße 10, DE 72076, Tübingen, Germany. School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 70211 Kuopio, Finland
- 4. Laboratory of Molecular Biology applied to Diagnosis (LBMAD), Department of Pharmacy, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP, Brazil
Description
HDAC1 molecular dynamics simulations with co-crystallized ligand and proposed novel cinnamyl-hydroxamate anticancer agents.
Details regarding the simulation method can be found in the respective publication.
Files
HDAC1_11b.zip
Files
(3.5 GB)
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