Published August 31, 2020
| Version 4.0.3 (Merlion)
Software
Open
SimThyr
Contributors
Other:
Project manager:
Related person:
Researchers:
Supervisors:
- 1. Bergmannsheil University Hospitals, Ruhr University of Bochum
- 2. Klinikum Luedenscheid
- 3. North Lakes Clinical
- 4. Ludwig-Maximilian-University of Munich
Description
SimThyr is a numeric simulator of pituitary-thyroid feedback control (aka thyrotropic feedback control, hypothalamus-pituitary-thyroid axis or thyroid homeostasis), based on a non-linear MiMe-NoCoDI model of the information processing structure. Its intended main use is in education and in silico research.
Files
Kubota_et_al._2010_v1.2.zip
Files
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Additional details
Identifiers
References
- J. W. DIETRICH, A. TESCHE, C. R. PICKARDT & U. MITZDORF (2004) THYROTROPIC FEEDBACK CONTROL: EVIDENCE FOR AN ADDITIONAL ULTRASHORT FEEDBACK LOOP FROM FRACTAL ANALYSIS, Cybernetics and Systems, 35:4, 315-331, DOI: 10.1080/01969720490443354
- Johannes W. Dietrich, Gabi Landgrafe, and Elisavet H. Fotiadou, "TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis," Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. https://doi.org/10.1155/2012/351864.
- Midgley JEM, Hoermann R, Larisch R, Dietrich JW. Physiological states and functional relation between thyrotropin and free thyroxine in thyroid health and disease: in vivo and in silico data suggest a hierarchical model. Journal of Clinical Pathology 2013;66:335-342.
- Hoermann R, Midgley JE, Larisch R, Dietrich JW. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur J Endocrinol. 2013 Jan 17;168(2):271-80. doi: 10.1530/EJE-12-0819. PMID 23184912.
- Hoermann R, Midgley JE, Larisch R, Dietrich JW. Integration of Peripheral and Glandular Regulation of Triiodothyronine Production by Thyrotropin in Untreated and Thyroxine-Treated Subjects. Horm Metab Res. 2015 Aug;47(9):674-80. doi: 10.1055/s-0034-1398616. PMID 25750078.
- Dietrich JW, Landgrafe-Mende G, Wiora E, Chatzitomaris A, Klein HH, Midgley JE, Hoermann R. Calculated Parameters of Thyroid Homeostasis: Emerging Tools for Differential Diagnosis and Clinical Research. Front Endocrinol (Lausanne). 2016 Jun 9;7:57. doi: 10.3389/fendo.2016.00057. PMID: 27375554; PMCID: PMC4899439.
- Chatzitomaris A, Hoermann R, Midgley JE, Hering S, Urban A, Dietrich B, Abood A, Klein HH, Dietrich JW. Thyroid Allostasis-Adaptive Responses of Thyrotropic Feedback Control to Conditions of Strain, Stress, and Developmental Programming. Front Endocrinol (Lausanne). 2017 Jul 20;8:163. doi: 10.3389/fendo.2017.00163. PMID: 28775711; PMCID: PMC5517413.
- Hoermann R, Midgley JEM, Larisch R, Dietrich JWC. Advances in applied homeostatic modelling of the relationship between thyrotropin and free thyroxine. PLoS One. 2017 Nov 20;12(11):e0187232. doi: 10.1371/journal.pone.0187232. PMID: 29155897; PMCID: PMC5695809.
Subjects
- Homo sapiens
- http://www.eol.org/pages/327955/
- Hypothalamus
- https://www.ncbi.nlm.nih.gov/mesh/68007031
- Pituitary Gland
- https://www.ncbi.nlm.nih.gov/mesh/68010902
- Thyroid Gland
- https://www.ncbi.nlm.nih.gov/mesh/68013961
- Thyrotropin
- https://www.ncbi.nlm.nih.gov/mesh/68013972
- Thyroid Hormones
- https://www.ncbi.nlm.nih.gov/mesh/68013963
- Homeostasis
- https://www.ncbi.nlm.nih.gov/mesh/68006706