The transcriptomic response of murine thyroid to iodide overload and the role of the Nrf2 antioxidant system
Creators
- 1. Service of Endocrinology and Diabetology, Lausanne University Hospital, and Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland
Description
Wild-type and Nrf2(Nfe2l2) knockout male C57BL6J mice 3-4 months old were administred 0.05% NaI in their drinking water for 7 days. Control mice were administered regular drinking water. After this treatment mice were euthanized and thyroids were excised for RNA preparation and then for mRNA and miRNA RNAseq.
The file titled "metadata RNAseq mRNA thyroid" contains the experimental information as well as the allocation of sample numbers to the relevant groups. Briefly,
806 Knockout Iodide
829 Wild type Iodide
815 Knockout Control
811 Knockout Control
801 Knockout Iodide
836 Wild type Control
838 Wild type Control
807 Knockout Iodide
834 Wild type Control
827 Wild type Iodide
831 Wild type Iodide
804 Knockout Iodide
825 Wild type Iodide
841 Wild type Control
812 Knockout Control
803 Knockout Iodide
810 Knockout Control
The fastq data have been uploaded. The ones with "miRNA" in their file name refer to miRNA sequencing. All the others refer to mRNA sequencing.
Files
Files
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