Neural activity during a simple reaching task in macaques is counter to gating and rebound in basal ganglia-thalamic communication
Authors/Creators
- 1. University Medical Center Hamburg-Eppendorf
- 2. University of Pittsburgh
- 3. Columbia University Medical Center
- 4. University of Notre Dame
Description
Task-related activity in the ventral thalamus, a major target of basal ganglia output, is often assumed to be permitted or triggered by changes in basal ganglia activity through gating- or rebound-like mechanisms. To test those hypotheses, we sampled single-unit activity from connected basal ganglia output and thalamic nuclei (globus pallidus-internus, GPi, and ventrolateral-anterior nucleus, VLa) in monkeys performing a reaching task. Rate increases were the most common peri-movement change in both nuclei. Moreover, peri-movement changes generally began earlier in VLa than in GPi. Simultaneously-recorded GPi-VLa pairs rarely showed short-timescale spike-to-spike correlations or slow across-trials covariations and both were equally positive and negative. Finally, spontaneous GPi bursts and pauses were both followed by small, slow reductions in VLa rate. These results appear incompatible with standard gating and rebound models. Still, gating or rebound may be possible in other physiological situations: Simulations show how GPi-VLa communication can scale with GPi synchrony and GPi-to-VLa convergence, illuminating how synchrony of basal ganglia output during motor learning or in pathological conditions may render this pathway effective. Thus, in the healthy state, basal ganglia-thalamic communication during learned movement is more subtle than expected, with changes in firing rates possibly being dominated by a common external source.
Notes
Code and data can be used to plot Fig. 2-6 of the manuscript, and Supporting Information Fig. S2-S14:
Fig. 2: Fig2_3_S8_S9.m
Fig. 3: Fig2_3_S8_S9.m
Fig. 4: Fig4_S10to13.m
Fig. 5: Fig5_S14.m
Fig. 6: Fig6.m
S2: FigS2.m
S3: FigS3.m
S4: FigS4.m
S5: FigS5.m
S6: FigS6_S8.m
S7: FigS7.m
S8: FigS6_S8.m, Fig2_3_S8_S9.m
S9 : Fig2_3_S8_S9.m
S10: Fig4_S10to13.m
S11: Fig4_S10to13.m
S12: Fig4_S10to13.m
S13: Fig4_S10to13.m
S14: Fig. 5: Fig5_S14.m
Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: S01NS113817
Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01NS091853
Funding provided by: National Institute of Neurological Disorders and Stroke
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000065
Award Number: R01NS070865
Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DMS1516288
Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DMS1724240
Funding provided by: Center for Neuroscience Research in Non-human primates*
Crossref Funder Registry ID:
Award Number: 1P30NS076405-01A1
Funding provided by: National Science Foundation
Crossref Funder Registry ID: http://dx.doi.org/10.13039/100000001
Award Number: DMS-1654268
Funding provided by: Neuronex**
Crossref Funder Registry ID:
Award Number: DBI-1707400
Funding provided by: Netherlands Organization for Scientific Research**
Crossref Funder Registry ID:
Award Number: 613.009.012
Funding provided by: Center for Neuroscience Research in Non-human primates
Crossref Funder Registry ID:
Award Number: 1P30NS076405-01A1
Funding provided by: Neuronex*
Crossref Funder Registry ID:
Award Number: DBI-1707400
Funding provided by: Netherlands Organization for Scientific Research*
Crossref Funder Registry ID:
Award Number: 613.009.012
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