Published August 13, 2020
| Version 1.0.0
Dataset
Open
Human and mouse ALS histopathological tissue sections co-stained for FUS, SFPQ, CHAT and DAPI
Creators
- 1. Idiap Research Institute
- 2. Francis Crick Institute
- 3. University College London
Description
Multichannel microscopy data from histopathological sections of
1/ SOD1- and VCP-mutant mouse models together with control co-stained for SFPQ, FUS, CHAT and DAPI
The moues folder contains
2/ Healthy and sporadic ALS patients either co-stained for SFPQ or FUS together with CHAT and DAPI
These two series of multichannel fluorescent microscopy data have been used in several manuscripts including:
- Luisier R, Tyzack GE, Hall CE, Mitchell JS, Devine H, Taha DM, et al. Intron retention and nuclear loss of SFPQ are molecular hallmarks of ALS. Nat Commun 2018; 9: 2010.
- Tyzack GE, Luisier R, Taha DM, Neeves J, Modic M, Mitchell JS, et al. Widespread FUS mislocalization is a molecular hallmark of amyotrophic lateral sclerosis. Brain 2019; 142: 2572–80.
Files
RawHumanImages.zip
Files
(2.1 GB)
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