UŞAQLIQ BOYNU DİSPLAZİYALARINDA PD-L1 ÇALIŞMALARIN PROQNOSTİK ƏHƏMİYYƏTİ

The article is included the clinical and morphological features of 35 patients who had been diagnosed and treated with cervical dysplasia and reflected the immununistochemical results of PD-L1 expression in atypical cells. By standardized immunochemical methods, receptor levels vary depending on the degree of intraepitelial dysplasia. In patients with CIN I, cells were not stained at all (negative PD-L1 reaction), PD-L1 expression in CIN II was 1+ and 2+ in 76.9±5.6%  , and 3+ in 23.1±5.3%  of patients (p<0.05). In patients with CIN III, 3+ cases (severe staining) were detected in 66.7±4.2% and cases of 2+ (moderate staining) in 33.3±4.9% of women. Thus, expression of the PD-L1 receptor, known as anti tumor immunitite regulator is closely related to dysplastic processes that begin in the tissue. By other words, the detection this receptor expression in patients with CIN diagnosis(especially CIN III) can play an important  role in the selection of treatment tactics and assessment of prognosis.