Published August 21, 2018 | Version v1
Journal article Open

Facile synthesis of some oxazepine-steroid using three component system

Creators

  • 1. Laboratory of Pharmaco-Chemistry at the Faculty of Chemical Biological Sciences of the University Autonomous of Campeche, Av. Agustín Melgar s/n, Col. Buenavista, C. P. 24039, Campeche, Campeche, México.
  • 2. Escuela Nacional de Ciencias Biológicas del Instituto Politécnico Nacional. Prol. Carpio y Plan de Ayala s/n Col. Santo Tomas, México, D.F. C.P. 11340.
  • 3. Facultad de Nutrición, Universidad Veracruzana. Médicos y Odontólogos s/n, 91010, Xalapa, Veracruz. México.

Description

There is a great interest in the development of several oxazepine derivatives in both pharmacy and organic chemistry fields such as antidepressant (amoxapine) and schizophrenia (loxapine). In search of new oxazepine analogs some methods use several reagents; however, some of these reagents are expensive and require special conditions for their handling. Therefore, the aim of this study was synthesizing some oxazepine-steroid using three component system (steroid, acetonitrile derivatives and 5-hexyn-1-ol). The chemical structure a purity of compounds was confirmed by melting point, infrared spectra, NMR spectroscopic data and mass spectrometry. The results shown the following; 1) the reagents used for the preparation of oxazepine derivatives does not require special conditions and are facile of handling; 2) the yielding of oxazepine derivatives are relatively good. All these data indicate that production of oxazepine derivatives could be carried out on a larger scale.

Files

Parana Journal of Science and Education (PJSE) – v. 4, n. 6, (34-45) August 21, 2018 - Figueroa Valverde et al..pdf

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