Published May 21, 2019 | Version v1
Journal article Open

Kinetic Analysis of Catalytic Organic Reactions Using a Temperature Scanning Protocol

  • 1. The Scripps Research Institute
  • 2. Pfizer Worldwide Research and Development

Description

Experimental and kinetic modelling studies are presented to describe the development of temperature scanning reaction progress protocol for batch reactions. Coupled with graphical manipulations, this approach enables the expansion of in-situ kinetic studies from a focus on isothermal concentration profiles to include reaction temperature as a parameter for rapid kinetic and mechanistic analysis.

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Funding

Mechanistic Rationalization of New Acetyl-Protected Amino Quinoline (APAQ) Ligands in Pd-Catalyzed Enantioselective Methylene C(sp3)-H Bond Activation P2ZHP2_178035
Swiss National Science Foundation