krassowski/drug-disease-profile-matching: v1.0

Multi-omics disease sub-type specific drug repositioning aided with expression signatures from ConnectivityMap.

Research questions:

• Do the signature-based drug repurposing/repositioning algorithms perform better on the cancer stratifications based on multi-omic methods rather than older expression-based stratifications?
• How good are the signature-based methods in the first-place?

See the structured abstract for graphical illustrations, details and results.

The code in this repository was written as a part of MRes research project at Imperial College London.

This version reflects the state of the project after MRes completion.