Manifestation of false Developmental Reprogramming in adult age: Faulty Hormonal Imprinting and DOHaD.

The paper calls attention to the similarities between hormonal imprinting (published in 1980 by Biological Reviews of Cambridge Philosophical Society as well as in Horm Metab Res, 1984; and DOHaD (Developmental Origin of Health and Disease), published in 1986 by Lancet. Both theories point to a relationship between an event (reprogramming) during ontogenetic development and the manifestation of an alteration (disease) in adult age. Hormonal imprinting and its faulty variants had been justified in animal experiments, while DOHaD were verified using epidemiological-statistical analyses. The two theories supplement and support each other. For faulty imprinting only the encounter between the developing hormone receptor and the target hormone (imprinter) is needed at critical periods of development (perinatally, during adolescence or during differentiation of adult cells) , whilst DOHaD (in the present standpoint) requests the pathological state perinatally, as provocator. In addition to the original -perinatal- observations especially important the observation and registration of the non-perinatal (pubertal and adult) provocations. The precognition of both theories by doctors seems to be necessary at present and even more in the future, as the amount and variants of man-made synthetic molecules (e.g endocrine disruptors) are extremely growing in the human environment and their presence in the critical developmental periods of man can explain the proliferation of non-communicable diseases.